Pharmacokinetics Certificate

Pharmacokinetics Principles Primer
ACPE #: 0204-0000-22-700-H04-P

• Restate the definitions of half-life, elimination rate constant, volume of distribution, clearance, and steady state.
• Describe first-order, Michaelis-Menten, and zero-order elimination.
• Recognize multi-compartment and one-compartment distribution from plots of log concentration vs. time.
• Calculate half-life, volume of distribution, and clearance from one or more measured drug concentrations.
• Use half-life, volume of distribution, and clearance to predict drug concentrations from administered doses.
• Use half-life to estimate time to steady state and how much time must elapse for a concentration to decrease to a new concentration.
• Discuss population pharmacokinetic values and dosing strategies for select drugs that take into account patient characteristics.
• Identify the appropriate equations that describe how doses are administered.
• Use population pharmacokinetic values and appropriate equations to determine dosing regimens to produce desired drug concentrations. 

Therapeutic Drug Monitoring and Renal Dosing Issues
ACPE #: 0204-0000-22-701-H04-P

• Recognize issues that reduce the quality of the therapeutic drug monitoring system.
• Describe issues that enhance the risk of making inappropriate dosage regimen decisions.
• Identify opportunities to improve therapeutic drug monitoring systems.
• Use formulas to estimate renal function in adults and children based on serum creatinine and patient characteristics.
• Adjust the dose and/or interval of drugs with significant renal elimination based on estimates of diminished renal function. 

Aminoglycoside Pharmacokinetics
ACPE #: 0204-0000-22-702-H04-P

• Calculate elimination rate constant, half-life, and volume of distribution from measured concentrations.
• Recommend dosing regimens based on calculated pharmacokinetic parameters.
• Design dosing regimens using elimination rate constant, half-life, volume of distribution, and clearance estimated from population pharmacokinetic data and patient characteristics.
• Apply variables to design a large dose, extended interval dosing regimens, including such things as age, creatinine clearance, and the best patient weight to use for dose recommendations. 

Anticonvulsant Pharmacokinetics: Part 1
ACPE #: 0204-0000-22-703-H04-P

• Calculate phenobarbital pharmacokinetic parameters using population-based dosing strategies and table data or from measured concentration(s).
• Use estimated or calculated phenobarbital pharmacokinetic values to predict doses to achieve desired steady state concentrations or concentrations from a dosing schedule being administered.
• Calculate valproic acid pharmacokinetic parameters using population-based dosing strategies and table data or from measured concentration(s).
• Use estimated or calculated valproic acid pharmacokinetic values to predict doses to achieve desired steady state concentrations or concentrations from a dosing schedule being administered. 

Anticonvulsant Pharmacokinetics: Part 2
ACPE #: 0204-0000-22-704-H04-P

• Calculate carbamazepine pharmacokinetic parameters using population-based dosing strategies and table data or from measured concentration(s).
• Use estimated or calculated carbamazepine pharmacokinetic values to predict doses to achieve desired steady state concentrations or concentrations from a dosing schedule being administered.
• Calculate phenytoin pharmacokinetic parameters using population-based dosing strategies and table data or from measured concentration(s).
• Use estimated or calculated phenytoin pharmacokinetic values to predict doses to achieve desired steady state concentrations or concentrations from a dosing schedule being administered. 

Digoxin and Lithium Pharmacokinetics
ACPE #: 0204-0000-22-705-H04-P

• Calculate digoxin pharmacokinetic parameters using population-based dosing strategies and table data or from measured concentration(s).
• Use estimated or calculated digoxin pharmacokinetic values to predict doses to achieve desired steady state concentrations or concentrations from a dosing schedule being administered.
• Calculate lithium pharmacokinetic parameters using population-based dosing strategies and table data or from measured concentration(s).
• Use estimated or calculated lithium pharmacokinetic values to predict doses to achieve desired steady state concentrations or concentrations from a dosing schedule being administered. 

Vancomycin Pharmacokinetics
ACPE #: 0204-0000-22-706-H04-P

• Calculate vancomycin pharmacokinetic parameters using population-based dosing strategies and table data or from measured concentration(s).
• Use estimated or calculated vancomycin pharmacokinetic values to predict doses to achieve desired steady state concentrations or to predict concentrations from a dosing schedule being administered.
• Use estimated or calculated vancomycin pharmacokinetic values to predict doses to achieve desired area under the curve / minimum inhibitory concentration (AUC/MIC) ratios or to predict AUC/MIC from a dosing schedule being administered.